Related studies of Yu’s Yang Engergy+
In his clinical practices, Dr. Yu found that Yang deficiency (mainly shown as cold syndrome) exist along with the important diseases in many patients, and this kind of Yang deficiency is usually the origin of diseases, and also is the primary cause of the long-term unhealed diseases. Dr. Yu made some amendment on the basis of the most famous Chinese traditional medical Yang reinforcing prescription “Jin-Gui Shen Qi Wan” and used in clinical practice and achieved good treatment effects.
In Chinese traditional medicine, Yangqi is not only related to the coldness or hotness of the body, but also related to the body's resistance to the outside world, even related to the life-span of a person; therefore, the Yang reinforcement is critical for Yang efficiency (mainly shown as cold syndrome) people.
Dr. Yu added ligusticum chuanxiong hort, tangerine peel and taxillus chinensis on the basis of “Jin-Gui Shen Qi Wan”, which not only preserves the effects of the original prescription, but also makes the prescription more suitable for the stomach, easier for absorption, and more efficient for arthralgic patients.
Pharmaceutical studies of “Jin-Gui Shen Qi Wan”
1.1 Nervous system Jiayi Chen et al. [1] investigated the effects of “Jin-Gui Shen Qi Wan” on the learning and memory abilities of Yang deficient mice caused by hydrocortisone and naturally aging rats of more than 18 months, the results showed that “Jin-Gui Shen Qi Wan” could significantly strengthen the learning and memory functions of Yang deficiency mice and old rats. In the same time, they detected the level of lipid peroxides in mitochondria within the brain tissue of mice, and the results showed that “Jin-Gui Shen Qi Wan” could significantly resist the elevation of lipid peroxides in mitochondria within the brain tissue of mice caused by hydrocortisone. Dongfang Wang et al. [2] explored the resistant effects of “Jin-Gui Shen Qi Wan” on the gentamicin ototoxicity through the observation of the changes in the apparent animal behavior, body temperature, oxygen consumption, as well as stress capacity. The results showed that “Jin-Gui Shen Qi Wan” could significantly reduce the brain stem auditory evoked potential of guinea pigs with ear toxicity, and it also had good effects on the recovery of the overal functional status of the animals.
1.2 Immune system Xuyi Liu et al. [3] observed the effects of “Jin-Gui Shen Qi Wan”decoction on the immune functions of male Swiss mice, and they found that this prescription could significantly enhance the phagocytosis function of the mice peritoneal macrophages. The results showed that, the phagocytic rate and phagocytic index of the peritoneal macrophages inthe treated group of mice were significantly higher than that of the control group, and the differences in treatment efficiency between groups were significant(P <0.01).
1.3 Endocrine system Chaofan Chow et al. [4] pointed that dysfunction of the hypothalamus - pituitary - adrenal cortex system might appear in Yang deficiency people or animals, however, the above pathological changes could usually be improved to varying degrees or even completely recover to normal. This demonstrated that Yang reinforcing medicines not only have cortisone-like positive functions while avoiding the side effects of hormonal drugs, but also could resist the feedback inhibiting effects of exogenous sex hormones and prevent the shrinkage of the adrenal cortex.
1.4 Genital system Qingping Chen et al. [5] used the 8% aqueous solution of “Jin-Gui Shen Qi Wan” in mice through intragastric administration for 1ml/20g once a day for continuous 8 weeks, and observed the effects of this prescription on the sex hormone levels of late fertility mice. The results showed that “Jin-Gui Shen Qi Wan” could significantly improve the serum testosterone level of aged male rats and the serum estradiol level of aged female rats respectively, and it could also significantly increase the weight of both of the testis of aged male rats. Studies of Junying Di et al. [7] discovered that “Jin-Gui Shen Qi Wan” could significantly improve the cAMP level of damaged testis tissues of rats, which implied that the regulation of body hormone levels and recovery of endocrine function by the regulation of cAMP level might be one of the mechanisms of the effects of “Jin-Gui Shen Qi Wan”.
1.5 Circulation system Jianxin Zhang et al. [8] observed the pharmacologic actions of “Jin Kui Shen Qi” oral liquid on the cardiovascular system through animal experiments. The results showed that “Jin Kui Shen Qi” oral liquid could significantly prolong the atmospheric hypoxia survival time of mice, significantly improve the acute myocardial ischemia rats induced by pituitrin, significantly reduce the incidence rate of fibrillation ventricular in mice caused by chloroform, significantly prolong the occurrence of aconitine-induced arrhythmia occurs, significantly inhibit the platelet aggregation function, and thus the study provides an experimental basis for the clinical application of this prescription for the prevention and treatment of cardiovascular diseases.
1.6 Metabolism
1.6.1 Carbohydrate metabolism Jinxiao Dao et al. [9] investigated the effects of extracts of “Jin Kui Shen Qi Wan” on the glucose tolerance ability of rats: in order to observe the effects of “Jin Kui Shen Qi Wan” on the glucose tolerance ability in rats, oral glucose load test and intravenous glucose load test for rats were carried out in the absence of anesthesia, and in the same time, the dynamic changes of blood glucose and insulin were analyzed. The results showed that “Jin Kui Shen Qi Wan” might produce hypoglycemic effects by acting on the sympathetic nervous system.
1.6.2 Lipid metabolism Meijuan Yu et al. [10] observed the effects of “Jin Kui Shen Qi Wan” on the alimentary hyperlipidemia in quails. The results showed that the serum total cholesterol (TCH) and triglycerides (TG) levels in the “Jin Kui Shen Qi Wan” group were significantly lower than the high-fat group, and the serum high-density lipoprotein - cholesterol (HDL-ch) and α-lipoprotein levels was significantly increased compared with the high-fat group, which indicated that “Jin Kui Shen Qi Wan” could improve the serum HDL-ch and α-lipoprotein concentration in high-fat diet animals, and had a certain degree of inhibition effects on the hypercholesterolemia and hypertriglyceridemia for animals.
1.6.3 Amino acid metabolism Animal experiments showed that the GSH (reduced glutathione) and GSSG (oxidized glutathione) content decreased significantly in the crystalline lens of cataract patients. Kosobe yang [11] reported a study in which Wistar rats of 24 months old were used as experimental objects, the rats were fed with “Jin Kui Shen Qi Wan” extracts by oral by a dosage of 1g/kg for continuous 12 months, and the metabolism status of glutathione in the bodies of the tested rats in 36-month-old were observed. They found that the GSH and GSSG levels increased significantly in the crystalline lens and spermary of the group of rats administrated with “Jin Kui Shen Qi Wan”, and the plasma level of GSH increased significantly. Thus, this study provided experimental evidence for the application of this prescription in the prevention of cataractous eyes.
1.7 Anti-fatigue effects Zhufen Jiang et al. [12] randomized 30 Kunming mice including males and females and observed the anti-fatigue effects of “Jin Kui Shen Qi Wan” and “Jin Kui Shen Qi oral liquid”. 30 minutes after intragastric administration of the medicine, swimming tests (anti-fatigue tests) were carried out, the results showed that both “Jin Kui Shen Qi Wan” and “Jin Kui Shen Qi oral liquid” could improve the survival rate of mice by more than 50%.
1.8 Anti-aging effects Hongyang Liu et al. [13] observed the anti-aging effects of the water solution of “Jin Kui Shen Qi Wan” on mice of different ages. The results showed that this prescription could relief the liver damages caused by free radicals and thus reduce the lipid peroxides (LPO) level in the liver; in the same time, this prescription also had a certain inhibition effects on the activities of the brain monoamine oxidase (MAO), and thus suggesting that “Jin Kui Shen Qi Wan” might be a satisfactory anti-aging agent.
1.9 Anti-mutagenic effects Mingyan Wang et al. [14] used the bone marrow cells of pure breed ICR mice as experimental material, and took the sister chromatid exchanges (SCE) induced by well admitted mutagen of cyclophosphamide (CCP) as detection index, they observed the effects of “Jin Kui Shen Qi Wan” on the SCE in the bone marrow cells of ICR mice. They found that “Jin Kui Shen Qi Wan” had significant inhibition effects on SCE, and thus suggesting that this prescription had potential values in the prevention of tumors.
1.10 Anti-radiation damages Xiaowei Zheng et al. [15] observed the protective effects of “Jin Kui Shen Qi Wan” on the chronic ionizing radiation damages of SD rats. The results showed that “Jin Kui Shen Qi Wan” could significantly reduce the aberration rate of the bone marrow cells of rats induced by radiation, and could also correct the decrease of the total number of white blood cells induced by radiation in rats, and thus suggesting that this prescription has satisfactory relief effects on radiation damages.
References
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