Related studies of Yu’s Yin Energ+ and Bone Strong+

Yin Enery+ (Bone Strong+) is a new prescription of pure chinese medicine for the treatment and prevention of osteoporosis promoted by Dr. Yu according to his deep knowledge and years of clinical studies and practices. Dr. Yu had been the chief editor of the parts of traditional medicine and acupuncture of the book Practical Osteoporosis due to his achievements in the traditional treatment of osteopathy and osteoporosis, and this book has become one of the most professional reference books.

Yin Energ+ and Bone Strong+ prescription of Dr. Yu is based on the famous prescription of “Liu Wei Di Huang Wan”of the Song dynasty. “Liu Wei Di Huang Wan” is an important kidney reinforcing prescription in Chinese traditional medicine. In Chinese traditional medicine, the cause of osteoporosis is the degeneration of kidney qi (for details please refer to the part of the functions of kidney), for women, the kidney qi is most enough when they are 4×7（28）years old, and when their hair is long and beautiful, the bodies are strong and the functions reach the peak status, when they are ×7（35）years old, the kidney qi begins to degenerate, their complexion begins to become sallow and not ruddy any more, and they begin to lose hair, the bodies begin to degenerate; for men, they reach the peak and begin to degenerate when they are 4×8 (32) an 5×8（40）years old respectively. Chinese people clearly realized this 2000 years ago: the loss of calcium and the degeneration of body functions are due to the level of kidney qi, the more is the kidney qi, the less loss of calcium, and the body would be stronger, and thus the lifetime would be longer. It is due to the application of these principles that makes the sclerotin of Chinese people is not worse than that of western people, and the lifetime is not less than that of the western people even in the conditions of fewer intakes of meats and milk food. “Liu Wei Di Huang Wan”is one of the most famous kidney reinforcing prescriptions, and it could be used for any women of more than 28 years old and any men of more than 32 years old.

Why did Dr. Yu amend the prescription?
Firstly, “Liu Wei Di Huang Wan”is the most basic prescription for kidney reinforcement, and Chinese traditional medical physicians would usually modify it on this basis in clinical practice. Secondly, for relatively obese people and people whose digestive function is not good enough, “Liu Wei Di Huang Wan”is not suitable for long-term use, however, the amended prescription could be used for any people (except people who are allergic to this prescription); thirdly, the amended prescription is apparently better than the original one in the enhancement of calcium absorption, it also preserves the efficacies of the original prescription, and it is the results of the more than 20 years’ practice of Dr. Yu; fourthly, this prescription is Yin and Yang balanced and is suitable for people of different ages.

Does the Yin Enery+ (Bone Strong+) preserve the functions of “Liu Wei Di Huang Wan”?
The Yu’s Yin Energ+ and Bone Strong+ preserves the functions of the original prescription, and the calcium reinforcing efficacy is further enhanced, the shortcomings of the original prescription are removed, and thus it is more suitable for modern people.

The modern pharmacologic actions of “Liu Wei Di Huang Wan”?
“Liu Wei Di Huang Wan” has significant functions of immune strengthening, anti-aging, anti-fatigue, anti-hypothermia, tolerance to anoxia, blood lipids reduction, blood pressure reduction, blood glucose reduction, kidney function improvement, metabolism promotion and good body strengthening effects.

  1. Functions of anti-fatigue, anti-hypothermia, tolerance to anoxia are similar with that of ginseng.
  2. Effects on immune functions: it could activate the cellular immunity and antibody producing reactions, improve the functions of cellular immunity, promote the induction of interferon in tonsil cells, and improve the serum interferon level.
  3. Expansion of blood vessels, it could significantly reduce the blood pressure and improve the renal function for the arterial stenosis hypertension.
  4. Reduce the deposition of myocardium collagen, prevent and treat the cardiovascular damages caused by hypertension.
  5. Improve the blood rheology, lower the whole blood viscosity, plasma viscosity, and fibrinogen, inhibit the generation of oxygen free radicals in cardiac infarction, reduce the infarct size, prevent and treat coronary heart disease and myocardial infarction.
  6. Effects on the blood lipids, it could significantly reduce cholesterol, triglyceride and phosphatides, increase the levels of high density lipoproteins, improve the ratio of HDL-C/TC, promote the metabolism of lipids, and its long-term use could prevent atherosclerosis.
  7. Improve the autonomic nervous system dysfunction.
  8. Improve the gonadal dysfunction, improve the hormone secretion through acting on the hypothalamus - pituitary - gonadal axis, promote sperm production, improve sperm motility and enhance sexual function.
  9. Promote the renal excretion of metabolized product urea and protect the renal excretory function.
  10. Protection effects on damaged liver: it has no apparent effects on the normal ALT activities; however, it could significantly reduce the promotion effects of ALT activities induced by carbon tetrachloride, thioacetamide, and prednisolone.
  11. Increase the body weight of mice, enhance the body strength, prolong the swimming time, and activate the generative center of spleen lymph nodules of animals receiving chemical carcinogens.
  12. Enhance the mononuclear phagocytic activity of macrophage system, improve the survival time, and improve the intracellular CAMP level within the cervical cancer ascites U14 cells, increase the growth inhibition rate of cancer cells.
  13. Inhibit the tumor-induction rate of urethane and nitrosmines.
  14. For oesophagus epithelial hyperplasia, it could interrupt the canceration process, and thus could prevent the occurrence of esophageal cancer and reduce its incidence.
  15. The content of metzincin in the rhizoma alismatis of “Liu Wei Di Huang Wan”is high, and the content of chrome in the macrocarpium officinale nakai is high, and thus it has a certain effects on the prevention of aging and progeria.
  16. Make the glucose metabolism in red cells recover to normal.
  17. Resist the toxic and side-effects of chemotherapeutics, prolong the survival rate, protect the functions of red cells, white cells and platelets, prevent the damages in functions of the heart, liver and kidney, protect the activities of NK cells, and enhance the Transformation functions of T, B lymphocytes.

The effects of “Liu Wei Di Huang Wan” on the calcium?
The herbs included in “Liu Wei Di Huang Wan” have apparent stimulating effects on the formation of human bones. It has kidney reinforcing effects when women take it. However, it has not the adverse effects on the uterine like estrogens; kidney reinforcing medicine could inhibit the bone resorption for male osteoporosis patients, enhance the bone formation, and improve the clinical symptoms, thus, it is an ideal treatment for osteoporosis.

In addition, there are trace elements in the Chinese traditional medicine, which have significant effects on the bone metabolism. For example, appropriate amount of fluorine is benefit for the utilizaion of calcium and phosphor. Copper deficiency could cause diffuse osteoporosis, and fractures are prone to occur. For patients with deficiency of zinc and manganese, dysfunctions in the skeleton are prone to happen, and the bone friability would increase. It contains the trace elements including copper, zinc and manganese in the components of “Liu Wei Di Huang Wan” including cornus officinalis, prepared rhizome of rehmannia, dioscorea batatas and rhizoma alismatis etc. and thus this prescription could promote the normal operation of kidney metabolism and make the bones to grow strong and powerful.

In short, Liu Wei Di Huang Wan is an ideal drug for osteoporosis. It could be used for the prevention of osteoporosis and aging for people who do not suffer from osteoporosis, and be used for the treatment of patients who have already been suffering from osteoporosis. Thus, Liu Wei Di Huang Wan is useful for the middle-aged, and better for the elderly.

The effects of Liu Wei Di Huang Wan on the sexual hormone levels?
With the development of science technology and their clinical applications, some scientists discovered many new features of Liu Wei Di Huang Wan. For example, some domestic Chinese scholars pointed out that Liu Wei Di Huang Wan had wonderful efficacies in the strengthening of the immune system, resisting of radiation, tumor inhibition, regulation blood sugar metabolism regulating and nourishing the liver etc. the Department of Health of Taiwan also announced that Liu Wei Di Huang Wan has anti-aging, memory enhancement functions.

The pharmacological studies of By Liu Wei Di Huang Wan also showed that it could improve the estrogen levels, improve the body's endocrine function and internal environment so as to improve and eliminate a variety of clinical symptoms in menopausal women; in the same time, Liu Wei Di Huang Wan could also promote the calcium absorption and prevent osteoporosis; In addition, it has also been confirmed that Liu Wei Di Huang Wan could reduce the incidence of atherosclerosis and coronary heart diseases.

Modern pharmacological studies have proven the therapeutic effects Liu Wei Di Huang Wan in the male sexual dysfunctions. Experimental studies showed that Liu Wei Di Huang Wan could increase the weight of the epididymis, significantly increase the sperm count, strengthen the mating abilities, stimulate the hypothalamus - pituitary - adrenal system, and which is also the mechanism for its enhancement of sexual functions.

Reference Articles:

  1. Liu Wei Di Huang Tang on osteoporosis in rats and the biomechanical properties of bone calcium and phosphorus content of [J]; traditional Chinese medicine and clinical pharmacology, Han xu Hua, Shi-Min Wang, Nai-zheng; 2002; 03
  2. Traditional kidney-tonic formula treatment of osteoporosis in clinical research Zeng Chun Chang , 2005 096167 Guangzhou University of Chinese Medicine
  3. Liu Wei Di Huang Wan (Tang) Pharmacodynamic study of new advances , Zhang Bao-guo, Liu Qingfang, Chinese formula medicine 2007 07
  4. Liu Wei Di Huang Wan of serum Pharmaceutical Chemistry [A] Wang Jun; Zhang Ning; Wen-Jun Sun; Sun Hui; China Association of Integrative Medicine at the Seventh National Symposium of Experimental Medicine paper compilation of [C]; 2004
  5. kidney and postmenopausal osteoporosis relations [J]; Tan Jing, Cao Ye, such as; Guangxi Medical Journal 2001; 03
  6. Ear acupuncture and Liu Wei Di Huang Wan prevention and treatment of osteoporosis in ovariectomized femalerats experimental study [A]: Luo Xiaoguang Liu Guozhong guidance: Zhi-ray Lui Ming Zhuang ,[J] Chinese Acupuncture No. 11 2001
  7. Concentrated Liu Wei Di Huang Wan in Treating kidney senile osteoporosis clinical observation of 60 cases Dong Yueling [J] Clinical Journal of Traditional Chinese Medicine 2004 02